Custom Disease Models & Mouse Genetics

Genodis designs and generates genetically engineered mouse models (GEMMs) that faithfully recapitulate human disease mechanisms, with a strong focus on genome instability, aging, cancer and immune dysregulation. Using tissue-specific and inducible systems (e.g. Cre/loxP), we can restrict mutations to defined cell types, allowing precise dissection of pathways in vivo.

We provide:

  1. Design and validation of custom mouse models
  2. In vivo phenotyping and longitudinal follow-up
  3. Application of models for target validation and preclinical proof-of-concept studies

Genomics, Epigenomics & Functional Profiling

Building on deep expertise in genetics and genomics, Genodis performs comprehensive molecular profiling of disease models and biological samples.

Our services include:

  1. Whole-genome, exome or targeted sequencing
  2. Transcriptomic and epigenomic analyses (including 3D chromatin context)
  3. Integration of functional genomics with disease endpoints (cancer, aging, inflammatory and immune-mediated disorders)

These datasets support biomarker discovery, prognostic signatures and mechanistic insights that can directly feed into therapeutic programs.

Bioinformatics & Multi-Omics Data Analysis

Genodis offers end-to-end bioinformatics support for genetic, genomic and epigenomic projects. Leveraging high-performance computing and advanced analytical pipelines, we transform complex data into actionable biology.

Our services include:

  1. Study design, power calculations and analysis plans
  2. Processing and QC of NGS data (DNA/RNA/epigenomics)
  3. Differential expression and pathway analysis
  4. Network, systems-level and aging-/progeria-related signatures

We can support one-off analyses or act as a long-term bioinformatics partner embedded in your R&D pipeline.

Preclinical Discovery 
& Therapeutic 
Co-Development

Genodis is developing a pipeline of targeted biological and mRNA-based anti-inflammatory drugs, along with innovative delivery strategies (e.g. nanocarrier-mediated and oligonucleotide-based approaches).

Our services include:

  1. In vivo testing of candidate biologicals and mRNA constructs in relevant models
  2. Identification of prognostic markers and therapeutic response signatures
  3. Co-development of novel drug concepts focused on inflammation, aging and rare diseases

Our aim is to de-risk new modalities from target to preclinical package, enabling smoother transition to clinical development or partnering.

Research & Innovation Consulting 
(EU & International)

Genodis actively participates in national and European research and training projects, and leverages this experience to support partners in designing competitive, high-impact proposals.

Consulting services cover:

  1. Concept development and scientific positioning of genetics/genomics projects
  2. Integration of advanced models, multi-omics and biological drugs into RIA/IA, MSCA, EIC, ERC or national calls
  3. Workplan design (WPs, tasks, KPIs, risk management)
  4. Exploitation, IP and translational strategy for innovative therapeutics

We can act as scientific partner, work-package leader or external expert depending on the call and consortium.

Training & Capacity Building

A core mission of Genodis is to train the next generation of biologists, geneticists and bioinformaticians. 

In collaboration with universities and research institutes, we offer:

  1. Hosting of MSc and PhD research projects, including industrial PhDs
  2. Hands-on training in mouse genetics, advanced molecular biology, imaging and omics
  3. Short courses and workshops on experimental design, NGS, and bioinformatics

These activities strengthen local and European capacity in cutting-edge biotechnology and help retain talent within the EU.